منابع مشابه
Multiple Protein Structure Alignment by Deterministic Annealing
Although many algorithms have been developed so far for structure alignment problem based on either distancebased methods or vector-based methods, such as iterative dynamical programming, Monte Carlo simulation, graph theory, and mean field equations, only a few methods are published for multiple structure alignment, such as progressive structure alignment and Monte Carlo optimization. In this ...
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If we know the structures of the proteins A and B, and the function of protein A, then if we can detect structural similarity between A and B by producing an alignment between them, it can help us infer functionality of B. The problem of protein structure alignment is essentially similar to the sequence alignment; the fact that we have to do structural alignment in 3-d adds to the complexity of...
متن کاملProtein Threading Based on Multiple Protein Structure Alignment.
Protein threading, a method employed in protein three-dimensional (3D) structure prediction was only proposed in the early 1990's although predicting protein 3D structure from its given amino acid sequence has been around since 1970's. Here we describe a protein threading method/system that we have developed based on multiple protein structure alignment. In order to compute multiple structure a...
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Identifying common local segments, also called motifs, in multiple protein sequences plays an important role for establishing homology between proteins. Homology is easy to establish when sequences are similar (sharing an identity > 25%). However, for distant proteins, it is much more difficult to align motifs that are not similar in sequences but still share common structures or functions. Thi...
متن کاملProtein multiple sequence alignment.
Protein sequence alignment is the task of identifying evolutionarily or structurally related positions in a collection of amino acid sequences. Although the protein alignment problem has been studied for several decades, many recent studies have demonstrated considerable progress in improving the accuracy or scalability of multiple and pairwise alignment tools, or in expanding the scope of task...
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ژورنال
عنوان ژورنال: Protein Science
سال: 1994
ISSN: 0961-8368,1469-896X
DOI: 10.1002/pro.5560031025